课题组长

English

杨淑华     杨淑华 实验室

职称:教授
联系电话:86-10-62734838 (O); 86-10-62734390 (L)
E-mail: yangshuhua@cau.edu.cn
研究方向:植物响应低温胁迫的分子机制

教育背景
1987年-1991年,南开大学,理学学士学位
1991年-1994年,南开大学,理学硕士学位
1998年-2002年,新加坡国立大学,博士学位


工作经历
1994年-1998年,南开大学,助理研究员
2002年-2004年,美国康奈尔大学,助研、博士后
2005年-至今,中国农业大学,教授

主要研究方向
研究方向:植物响应低温胁迫的分子机制
       作为外界主要环境因子,温度影响植物的生长发育、植被的分布以及农作物的产量。我们实验室主要以拟南芥和玉米为研究材料,通过分子生物学、遗传学和生物化学等手段,研究植物应答低温胁迫的信号转导途径、低温信号与植物激素信号之间的交互作用,以及低温信号与生物胁迫信号之间的交互作用等。
 
发表论文/论著    (*通讯作者)

(*Corresponding author; #These authors contributed equally)
2022
1. Ding Y, Yang S* (2022) Surviving and thriving: How plants perceive and respond to temperature stress. Dev Cell doi: https://doi.org/10.1016/j.devcel.2022.03.010.
2. Qi L#, Shi Y#, Terzaghi W, Yang S*, Li J* (2022) Integration of light and temperature signaling pathways in plants. J Integr Plant Biol 64: 393-411.
3. Yang S* (2022) Cold responses in rice: From physiology to molecular biology. J Plant Physiol 269: 153602.
4. Pei D, Hua D, Deng J, Wang Z, Song C, Wang Y, Wang Y, Qi J, Kollist H, Yang S, Guo Y, Gong Z* (2022) Phosphorylation of the plasma membrane H+-ATPase AHA2 by BAK1 is required for ABA-induced stomatal closure in Arabidopsis. Plant Cell doi: 10.1093/plcell/koac106.
2021
1. Gong Z*, Yang S* (2021) Drought meets SWEET. Nat Plants (news and views) 8: 25-26.
2. Li Y, Shi Y, Fu D, Wu S, Li J, Liu H, Yang S* (2021) The CRY2-COP1-HY5-BBX7/8 module regulates blue light-dependent cold acclimation in Arabidopsis. Plant Cell 33: 3555-3573.
3. Chen R#, Deng Y#, Ding Y#, Guo J#, Qiu J#, Wang B#, Wang C#, Xie Y#, Zhang Z#, Chen J, Chen L, Chu C, He G, He Z, Huang Y, Xing Y, Yang S, Xie D*, Liu YG*, Li J* (2021) Rice functional genomics: decades’ efforts and roads ahead. Sci China Life Sci 65: 33-92.
4. Ma A#, ZhangD#, Wang G, Wang K, Li Z, Gao Y, Li H, Bian C, Cheng J, Han Y, Yang S, Gong Z*, Qi J* (2021) Verticillium dahliae effector VDAL protects MYB6 from degradation by interacting with PUB25 and PUB26 E3 ligases to enhance Verticillium wilt resistance. Plant Cell 33: 3675-3699.
5. Zeng R#, Li Z#, Shi Y, Fu D, Yin P, Cheng J, Jiang C, Yang S* (2021) Natural variation in a type-A response regulator confers maize chilling tolerance. Nat Commun 12: 4713. doi: 10.1038/s41467-021-25001-y.
6.Song Y#, Zhang X#, Li M#, Yang H, Fu D, Lv J, Ding Y, Gong Z, Shi Y*, Yang S (2021) The direct targets of CBFs: in cold stress response and beyond. J Integr Plant Biol 63:1874-1887.
7. Li J#, Zeng Y#, Pan Y#, Zhou L#, Zhang Z, Guo H, Lou Qi, Shui G, Huang H, Tian H, Guo Y, Yuan P, Yang H, Pan G, Wang R, Zhang H, Yang S, Guo Y, Ge S, Li J, Li Z* (2021) Stepwise selection of natural variations at CTB2 and CTB4a improves cold adaptation during domestication of japonica rice. New Phytol 231: 1056-1072.
8. Feng Y#, Wang Y#, Zhang G, Gan Z, Gao M, Lv J, Wu T, Zhang X, Xu X, Yang S*, Han Z* (2021) Group-C/S1 bZIP heterodimers regulate MdIPT5b to negatively modulate drought tolerance in apple species. Plant J 107: 399-417.
9. Lv J, Liu J, Ming Y, Shi Y, Song C, Gong Z, Yang S, Ding Y* (2021) Reciprocal regulation between the negative regulator PP2CG1 phosphatase and the positive regulator OST1 kinase confers cold response in Arabidopsis. J Integr Plant Biol 63: 1568-1587.
10. Chen X#, Ding Y#, Yang Y#, Song C, Wang B, Yang S, Guo Y, Gong Z* (2021) Protein kinases in plant responses to drought, salt, and cold stress. J Integr Plant Biol 63: 53-78.  Highly cited in ESI
11. Liu Q, Ding Y, Shi Y, Ma L, Wang Y, Song C, Wilkins KA, Davies JM, Knight H, Knight MR, Gong Z, Guo Y, Yang S* (2021) The calcium transporter ANNEXIN1 mediates cold-induced calcium signaling and freezing tolerance in plants. EMBO J 40: e104559. (Selected for F1000 Prime)
2020
1. Jiang B#, Shi Y#, Peng Y, Jia Y, Yan Y, Dong X, Li H, Dong J, Li J, Gong Z, Thomashow MF, Yang S* (2020) Cold-induced CBF-PIF3 interaction enhances freezing tolerance by stabilizing the phyB thermosensor in Arabidopsis. Mol Plant 13: 894-906. (Highlighted with a Spotlight article in Trends Plant Sci)
2. Dong X, Yan Y, Jiang B, Shi Y, Jia Y, Cheng J, Shi Y, Kang J, Li H, Zhang D, Qi L, Han R, Zhang S, Zhou Y, Wang X, Terzaghi W, Gu Y, Kang D*, Yang S*, Li J* (2020) The cold response regulator CBF1 promotes Arabidopsis hypocotyl growth at ambient temperatures. EMBO J 39: e103630. (Highlighted with a Spotlight article in Trends Plant Sci, Selected for F1000 Prime)
3. Yan Y, Li C, Dong X, Li H, Zhang D, Zhou Y, Jiang B, Peng J, Qin X, Cheng J, Wang X, Song P, Qi L, Zheng Y, Li B, Terzaghi W, Yang S, Guo Y, Li J* (2020) MYB30, a key negative regulator of Arabidopsis photomorphogenic development, acts to promote PIF4 and PIF5 protein accumulation in the light. Plant Cell 32: 2196-2215.
4. Gong Z#, Xiong L#, Shi H#, Yang S#, Herrera-Estrella LR#, Xu G#, Chao DY#, Li J, Wang PY, Qin F, Li J, Ding Y, Shi Y, Wang Y, Yang Y, Guo Y*, Zhu JK* (2020) Plant abiotic stress response and nutrient use efficiency. Sci China Life Sci 63, 635-674.
5. Ding Y, Shi Y, Yang S* (2020) Molecular regulation of plant responses to environmental temperatures. Mol Plant (invited Review) 13:544-564.
6. Tang K, Zhao L, Ren Y, Yang S, Zhu JK, Zhao C* (2020) The transcription factor ICE1 functions in cold stress response by binding to the promoters of CBF and COR genes. J Integr Plant Biol, 62: 258-263.
7. Zhu Y, Hu X, Duan Y, Li S, Wang Y, Rehman AU, He J, Zhang J, Hua D, Yang L, Wang L, Chen Z, Li C, Wang B, Song CP, Sun Q, Yang S, Gong Z* (2020) The Arabidopsis nodulin homeobox factor AtNDX interacts with AtRING1A/B and negatively regulates abscisic acid signaling. Plant Cell 32:703-721.
2019
1. Wang X, Ding Y, Li Z, Shi Y, Wang J, Hua J, Gong Z, Zhou JM, Yang S* (2019) PUB25 and PUB26 promote plant freezing tolerance by degrading the cold signaling negative regulator MYB15. Dev Cell 51: 222-235. (Selected for F1000 Prime)
2. Ye K#, Li H#, Ding Y, Shi Y, Song C, Gong Z, Yang S* (2019) BIN2 negatively regulates ICE1 stability in response to cold stress in Arabidopsis. Plant Cell 31: 2682-2696.
3. Ding Y, Lv J, Shi Y, Gao J, Hua J, Song C, Gong Z, Yang S* (2019) EGR2 phosphatase regulates OST1 kinase activity and freezing tolerance in Arabidopsis. EMBO J 38: e99819. (Selected for F1000 Prime)
4. Ding Y#, Shi Y#, Yang S* (2019) Advances and challenges in uncovering cold tolerance regulatory mechanisms in plants. New Phytol (invited Tansley Review) 222: 1690-1704.
5. Qin Y, Yang L, Sun Z, Wang X, Wang Y, Zhang J, Rehman AU, Chen Z, Qi J, Wang B, Song C, Yang S, Gong Z*(2019) Redox-mediated endocytosis of a receptor-like kinase during distal stem cell differentiation depends on its tumor necrosis factor receptor domain. Plant Physiol 181:1075-1095.
6. Wang X, Guo C, Peng J, Li C, Wan F, Zhang S, Zhou Y, Yan Y, Qi L, Sun K, Yang S, Gong Z, Li J* (2019) ABRE-BINDING FACTORS play a role in the feedback regulation of ABA signaling by mediating rapid ABA induction of ABA co-receptor genes. New Phytol 221: 341-355.
7. Feng Y, Liu J, Zhai L, Gan Z, Zhang G, Yang S, Wang Y, Wu T, Zhang X, Xu X, Han Z* (2019) Natural variation in cytokinin maintenance improves salt tolerance in apple rootstocks. Plant Cell Environ 42: 424-436.
2018
1. Shi Y#, Ding Y#, Yang S* (2018) Molecular regulation of CBF signaling in cold acclimation. Trends Plant Sci (invited review) 23: 623-637.
2. Ding Y, Jia Y, Shi Y, Song C, Gong Z, Yang S* (2018) OST1-mediated BTF3L phosphorylation positively regulates CBFs during plant cold responses. EMBO J 37: e98228.
3. Liu J#, Shi Y#, Yang S* (2018) Insights into the regulation of C-repeat binding factors in plant cold signaling. J Integr Plant Biol (invited review) 60: 780-795.
4. Huang X, Hou L, Meng J, You H, Li Z, Gong Z, Yang S, Shi Y*(2018) The antagonistic action of abscisic acid and cytokinin signaling mediates drought stress response in Arabidopsis. Mol Plant 11: 970-982.
5. Wang K#, He J#, Zhao Y, Wu T, Zhou X, Ding Y, Kong L, Wang X, Wang Y, Li J, Song CP, Wang B, Yang S, Zhu JK, Gong Z* (2018) EAR1 negatively regulates ABA signaling by enhancing 2C protein phosphatase activity. Plant Cell 30: 815-834.
6. Wei D, Liu M, Chen H, Zheng Y, Liu Y, Wang X, Yang S, Zhou M*, Lin J* (2018) INDUCER OF CBF EXPRESSION 1 is a male fertility regulator impacting anther dehydration in Arabidopsis. PLoS Genet 14: e1007695.
2017
1. Li H, Ding Y, Shi Y, Zhang X, Zhang S, Gong Z, Yang S* (2017) MPK3- and MPK6-mediated ICE1 phosphorylation negatively regulates ICE1 stability and freezing tolerance in Arabidopsis. Dev Cell 43: 630-642. (Highlighted with a Preview article in Dev Cell and a Spotlight article in Trends Plant Sci; Selected for F1000 Prime; 植物学报热点评)
2. Jiang B#, Shi Y#, Zhang X, Xin X, Qi L, Guo H, Li J*, Yang S* (2017) PIF3 is a negative regulator of the CBF pathway and freezing tolerance in Arabidopsis. Proc Natl Acad Sci USA 114: E6695-E6702. (Highlighted with a News & Views in Nat Plant and a Spotlight article in Trends Plant Sci)
3. Liu Z, Jia Y, Ding Y, Shi Y, Zhang X, Li Z, Guo Y, Gong Z, Yang S* (2017) Plasma membrane CRPK1-mediated phosphorylation of 14-3-3 proteins induces their nuclear import to fine-tune CBF signaling during cold response. Mol Cell 66: 117-128. (Highlighted with a Preview article in Mol Cell; Selected for F1000 Prime)
4. Li H#, Ye K#, Shi Y, Zhang X, Yang S* (2017) BZR1 positively regulates freezing tolerance via CBF-dependent and CBF-independent pathways in Arabidopsis. Mol Plant 10:549-559. (Highlighted with a Spotlight article in Mol Plant)
5. Zhang Z#, Li J#, Pan Y#, Li J#, Zhou L#, Shi H#, Zeng Y#, Guo H, Yang S, Zheng W, Yu J, Sun X, Li G, Ding Y, Ma L, Shen S, Dai L, Zhang H, Yang S, Guo Y, Li Z* (2017) Natural variation in CTB4a enhances rice adaptation to cold habitats. Nat Commun 8:14788.
6. Zhang Y#, Wang Y#, Liu J, Ding Y, Wang S, Zhang X, Liu Y, Yang S* (2017) Temperature-dependent autoimmunity mediated by chs1 requires its neighboring TNL gene SOC3. New Phytol 213:1330-1345.
7. Tong M, Kotur T, Liang W, Vogelmann K, Kleine T, Leister D, Brieske C, Yang S, Lüdke D, Wiermer M, Zhang Y, Li X*, Hoth S*. (2017) E3 ligase SAUL1 serves as a positive regulator of PAMP-triggered immunity and its homeostasis is monitored by immune receptor SOC3. New Phytol 215:1516-1532.
8. Huang X, Zhang X, Gong Z, Yang S, Shi Y* (2017) ABI4 represses the expression of type-A ARRs to inhibit seed germination in Arabidopsis. Plant J 89: 354-365.
2016
1. Jia Y, Ding Y, Shi Y, Zhang X, Gong Z, Yang S* (2016) The cbfs triple mutants reveal the essential functions of CBFs in cold acclimation and allow the definition of CBF regulons in Arabidopsis. New Phytol 212: 345-353. (Highlighted with a Commentary article in New Phytol)
2. Yu F, Lou L, Tian M, Li Q, Ding Y, Wu Y, Belda-Palazon B, Rodrigue P L, Yang S, Xie Q* (2016) ESCRT-I component VPS23A affects ABA signaling by recognizing ABA receptors for endosomal degradation. Mol Plant 9: 1570-1582.
2015
1. Ding Y, Li H, Zhang X, Xie Q, Gong Z, Yang S* (2015) OST1 kinase modulates freezing tolerance by enhancing ICE1 stability in Arabidopsis. Dev Cell 32: 278-289. (Highlighted with a Preview article in Dev Cell; Highlighted with an article in SCIENCE CHINA Life Sciences; 植物学报热点评)
2. Liu J#, Yang H#, Bao F, Ao K, Zhang X, Zhang Y, Yang S* (2015) IBR5 modulates temperature-dependent, R protein CHS3-mediated defense responses in Arabidopsis. PLoS Genet 11, e1005584. (Selected for F1000 Prime)
3. Kong L, Cheng J, Zhu Y, Ding Y, Meng J, Chen Z, Xie Q, Guo Y, Li J, Yang S, Gong Z* (2015) Degradation of the ABA co-receptor ABI1 by PUB12/13 U-box E3 ligases. Nat Commun 6: 8630. doi: 10.1038/ncomms9630.
4. Ji H, Wang Y, Cloix C, Li K, Jenkin G, Wang S, Shang Z, Shi Y, Yang S, Li X* (2015) The Arabidopsis RCC1 family protein TCF1 regulates freezing tolerance and cold acclimation through modulating lignin biosynthesis. PLoS Genet 11, e1005471.
5. Shi Y#, Ding Y#, Yang S* (2015) Cold signal transduction and its interplay with phytohormones during cold acclimation. Plant Cell Physiol (invited review) 56: 7-15.
6. Shi Y, Yang S* (2015) COLD1: a cold sensor in rice. Sci China Life Sci 58: 409-410.
2014
1. Bao F, Huang X, Zhu C, Zhang X, Li X, Yang S* (2014) Arabidopsis HSP90 protein modulates RPP4-mediated temperature-dependent cell death and defense responses. New Phytol 202: 1320-1334.
2. Song S, Huang H, Gao H, Wang J, Wu D, Liu X, Yang S, Zhai Q, Li C, Qi T, Xie D* (2014) Interaction between MYC2 and ETHYLENE INSENSITIVE3 modulates antagonism between jasmonate and ethylene signaling in Arabidopsis. Plant Cell 26: 263-279.
2013
1. Wang Y, Zhang Y, Wang Z, Zhang X, Yang S* (2013) A missense mutation in CHS1, a TIR-NB protein, induces chilling sensitivity in Arabidopsis. Plant J 75: 553-565.
2. Shi Y, Wang Z, Meng P, Tian S, Zhang X, Yang S* (2013) The glutamate carboxypeptidase AMP1 mediates ABA and abiotic stress responses in Arabidopsis. New Phytol 199: 135-150.
3. Guo L, Yang H, Zhang X, Yang S* (2013) Lipid transfer protein 3 as a target of MYB96 mediates freezing and drought stress in Arabidopsis. J Exp Bot 64: 1755-1767.
4. Li J#, Mu J#, Bai J#, Fu F, Zou T, An F, Zhang J, Jing H, Wang Q, Yang S, Zuo J* (2013) PARAQUAT RESISTANT 1, a Golgi-localized putative transporter protein, is involved in intracellular transport of paraquat. Plant Physiol 162: 470-483.
2012
1. Shi Y#, Tian S#, Hou L, Huang X, Zhang X, Guo H, Yang S* (2012) Ethylene signaling negatively regulates freezing tolerance by repressing expression of CBF and type-A ARR genes in Arabidopsis. Plant Cell 24: 2578-2595.
2011
1. Wang Z#, Meng P#, Zhang X, Ren D, Yang S* (2011) BON1 interacts with the protein kinases BIR1 and BAK1 in modulation of temperature-dependent plant growth and cell death in Arabidopsis. Plant J 67: 1081-1093.
2010
1. Huang X, Li J, Bao F, Zhang X, Yang S* (2010) A gain-of-function mutation in the Arabidopsis disease resistance gene RPP4 confers sensitivity to low temperature. Plant Physiol 154: 796-809.
2. Yang H, Shi Y, Liu J, Guo L, Zhang X, Yang S* (2010) A mutant CHS3 protein with TIR-NB-LRR-LIM domains modulates growth, cell death and freezing tolerance in a temperature-dependent manner in Arabidopsis. Plant J 63: 283-296.
3. Huang X, Li Y, Zhang X, Zuo J, Yang S* (2010) The Arabidopsis LSD1 gene plays an important role in the regulation of low temperature-dependent cell death. New Phytol 187: 301-312 (Cover story).
4. Liu D, Gong Q, Ma Y, Li P, Li J, Yang S, Yuan L, Yu Y, Pan D, Xu F, Wang NN* (2010) cpSecA, a thylakoid protein translocase subunit, is essential for photosynthetic development in Arabidopsis. J Exp Bot 61: 1655-1669.
2009及以前
1. Huang X, Zhang X, Yang S* (2009) A novel chloroplast-localized protein EMB1303 is required for chloroplast development in Arabidopsis. Cell Res 19: 1205-1216.
2. Gou M, Su N, Zheng J, Huai J, Wu G, Zhao J, He J, Tang D, Yang S, Wang G* (2009) An F-box gene, CPR30, functions as a negative regulator of the defense response in Arabidopsis. Plant J 60: 757-770.
3. Li Y#, Yang S#, Yang H, Hua J* (2007) The TIR-NB-LRR gene SNC1 is regulated at the transcript level by multiple factors. Mol Plant Microbe Interact 20: 1449-1456.
4. Yang H, Yang S, Li Y, Hua J* (2007) The Arabidopsis BAP1 and BAP2 genes are general inhibitors of programmed cell death. Plant Physiol 145: 135-146.
5. Chai MF, Wei PC, Chen QJ, An R, Chen YM, Chen J, Yang S*, Wang XC* (2006) NADK3, a novel cytoplasmic source of NADPH, is required under conditions of oxidative stress and modulates abscisic acid responses in Arabidopsis. Plant J 47: 665-674.
6. Yang S, Yang H, Grisafi P, Sanchatjate S, Fink GR, Sun Q, Hua J* (2006) The BON/CPN gene family represses cell death and promotes cell growth in Arabidopsis. Plant J 45: 166-179.
7. Yang S, Hua J* (2004) A haplotype-specific resistance gene regulated by BONZAI1 mediates temperature-dependent growth control in Arabidopsis. Plant Cell 16: 1060-1071.
8. Yang S*, Yu H, Xu Y, Goh CJ* (2003) Investigation of cytokinin-deficient phenotypes in Arabidopsis by ectopic expression of orchid DSCKX1. FEBS Lett 555: 291-296.
9. Yang S, Yu H, Goh CJ* (2003) Functional characterisation of a cytokinin oxidase gene DSCKX1 in Dendrobium orchid. Plant Mol Biol 51: 237-248.
10. Yang S, Yu H, Goh CJ* (2002) Isolation and characterization of the orchid cytokinin oxidase DSCKX1 promoter. J Exp Bot 53: 1899-1907.
11. Yu H, Yang S, Goh CJ* (2002) Spatial and temporal expression of the orchid floral homeotic gene DOMADS1 is mediated by its upstream regulatory elements. Plant Mol Biol 49: 225-237.
12. Yu H, Yang S, Goh CJ* (2001) Agrobacterium-mediated transformation of a Dendrobium orchid with the class 1 knox gene DOH1. Plant Cell Rep 20: 301-305.
13. Yu H, Yang S, Goh CJ* (2000) DOH1, a class 1 knox Gene, is required for maintenance of the basic plant architecture and floral transition in orchid. Plant Cell 12: 2143-2160.

中文文章
1. 杨淑华
#,巩志忠#,郭岩#,龚继明#,郑绍建#,林荣呈#,杨洪全#,毛龙#,秦峰#,罗利军#,张天真#,储成才#,赖锦盛#,晁代印,关雪莹,彭佳师,黄朝峰,蒋才富,王瑜,杨永青,施怡婷,丁杨林,马亮,种康* (2019) 中国植物应答环境变化研究的过去与未来. 中国科学:生命科学. 49:1457-1478
2. 刘静妍,施怡婷,杨淑华* (2017) CBF:平衡植物低温应答与生长发育的关键. 植物学报. 52: 689-698.
3. 丁杨林,施怡婷,杨淑华* (2015) 植物响应低温胁迫的分子机制研究. 中国科学:生命科学. 27: 398-405.
4. 邓 岩,王兴春,杨淑华*,左建儒* (2006) 细胞分裂素:代谢、信号转导、交叉反应与农艺性状改良. 植物学通报. 23: 478-498.