课题组长

English
毛同林
职称:教授
联系电话:86-10-62732330 (O);86-10-62734396 (L)
E-mail:
maotonglin@cau.edu.cn
研究方向:细胞骨架与植物生长和细胞形态建成的调控机制

毛同林,博士,教授,博士生导师
    1996年毕业于内蒙古农牧学院农学系,获学士学位;1999年获中国农业大学植物生理学与生物化学专业,理学硕士学位;1999年-2005年在中国农业科学院工作;2005年获中国农业大学植物学专业,理学博士学位,同年留校工作。2008年至2009年美国斯坦福大学卡耐基研究所,访问学者。
    2012 年获得 “国家优秀青年科学基金”资助  (2013-2015);2012年入选教育部“新世纪优秀人才支持计划”;2016年获得“国家杰出青年科学基金”资助(2017-2021)。近年来在 The Plant Cell,Plant Physiology,Journal of Cell Science 等刊物发表多篇研究论文。

主要研究方向

植物微管骨架(Microtubules, MTs)在调控植物生长、发育和植物细胞形态建成等生理过程中起着重要的作用。本课题组的主要研究方向涉及植物细胞骨架及其调节蛋白与光、植物激素和非生物逆境等上游调节和环境因子之间的功能关系。
1、植物细胞微管骨架调控下胚轴生长的分子机制。下胚轴细胞生长的调控一直是植物生理学中的研究热点问题。大量的研究表明光、植物激素(如生长素,赤霉素,油菜素内酯)以及钙离子等参与了下胚轴细胞生长的调控。本课题组重点研究了微管骨架及其调节蛋白在调控下胚轴细胞伸长生长中的生理学功能,以及它们与光、植物激素和钙离子等上游调控因子之间的功能关系,包括钙离子对微管去稳定蛋白MDP25功能的调控,植物激素油菜素内酯对微管去稳定蛋白MDP40转录水平的调控以及26S蛋白酶体途径对微管稳定因子WDL3蛋白水平的调控等诸多调控途径。

微管稳定因子WDL3通过26S蛋白酶体途径参与了拟南芥下胚轴对光反应的生理学过程(The Plant Cell. 2013: 25:1740-1755)

2. 细胞骨架参与非生物逆境的功能分析。植物在适应非生物逆境过程中,需要调控自身的生长、发育以使其完成生命周期,而细胞骨架在其中起着重要的作用。我们实验室致力于鉴定参与该过程的重要的骨架调控蛋白,并试图探讨它们调控的分子机制。

"
发表论文/论著    (*通讯作者)
Qianqian Ma#,Jingbo Sun#,and Tonglin Mao* (2016) Microtubule bundling plays a role in ethylene-mediated cortical microtubule reorientation in etiolated Arabidopsis hypocotyls. Journal of Cell Science 129:2043–2051(#These authors contributed equally)
Jingbo Sun#, Qianqian Ma#, and Tonglin Mao* (2015) Ethylene regulates Arabidopsis Microtubule-Associated Protein WDL5 in etiolated hypocotyl elongation. Plant Physiology 169:325-337(#These authors contributed equally)
Tao Qin#, Xiaomin Liu#, Jiejie Li, Jingbo Sun, Leina Song, and Tonglin Mao* (2014) Arabidopsis Microtubule-Destabilizing Protein 25 Functions in Pollen Tube Growth by Severing Actin Filaments. The Plant Cell 26:325–339 (#These authors contributed equally)
Xiaomin Liu#, Tao Qin#, Qianqian Ma, Jingbo Sun, Ziqiang Liu, Ming Yuan, and Tonglin Mao* (2013) Light-regulated hypocotyl elongation involves proteasome-dependent degradation of the microtubule regulatory protein WDL3 in Arabidopsis. The Plant Cell 25:1740-1755 (#These authors contributed equally)
Xianling Wang#, Jin Zhang#, MingYuan, David W. Ehrhardt, Zhiyong Wang, and Tonglin Mao* (2012) Arabidopsis MICROTUBULE DESTABILIZING PROTEIN40 is involved in brassinosteroid regulation of hypocotyl elongation. The Plant Cell 24: 4012-4025 (#These authors contributed equally)
Tao Qin, Jiejie Li, Ming Yuan,and Tonglin Mao* (2012) Characterization of the Role of Calcium in Regulating the Microtubule-Destabilizing Activity of MDP25. Plant Signaling & Behavior 7:708-710
Qun Zhang, Feng Lin, Tonglin Mao, Jianing Nie, Min Yan, Ming Yuan,and Wenhua Zhang (2012) Phosphatidic Acid Regulates Microtubule Organization by Interacting with MAP65-1 in Response to Salt Stress in Arabidopsis. The Plant Cell 24: 4555-4576.
Jiejie Li#, Xianling Wang#, Tao Qin#, Yan Zhang#, Xiaomin Liu, Jingbo Sun, Yuan Zhou, Lei Zhu, Ziding Zhang, Ming Yuan, and Tonglin Mao* (2011) MDP25, A Novel Calcium Regulatory Protein, Mediates Hypocotyl Cell Elongation by Destabilizing Cortical Microtubules in Arabidopsis. The Plant Cell  23: 4411-4427  (#These authors contributed equally)
Yang Zhao, Shuangshuang Zhao,Tonglin Mao, Xiaolu Qu, Wanhong Cao, Li Zhang, Wei  Zhang, Liu He, Sidi Li, Sulin Ren, Jinfeng Zhao, Guoli Zhu, Shanjin Huang, Keqiong Ye, Ming Yuan, and Yan Guo (2011) The Plant-Specific Actin Binding Protein SCAB1 Stabilizes Actin Filaments and Regulates Stomatal Movement in Arabidopsis. The Plant Cell  23 :2314-2330.
Qiutao Meng#, Jizhou Du#, Jiejie Li, Xiaomei Lü, Xian Zeng, Ming Yuan and Tonglin Mao* (2010) Tobacco microtubule-associated protein, MAP65-1c, bundles and stabilizes microtubules. Plant Molecular Biology  74:537-547. (#These authors contributed equally)
Hua Li#, Xian Zeng#, Zi-Qiang Liu, Qiu-Tao Meng, Ming Yuan and Tonglin Mao*(2009) Arabidopsis Microtubule-Associated Protein AtMAP65-2 acts as a microtubule stabilizer. Plant Molecular Biology  69: 313-324. (#These authors contributed equally)
Hua Li#, Tonglin Mao#, Ziding Zhang, Ming Yuan (2007) The AtMAP65-1 cross-bridge between microtubules is formed by one dimer. Plant and Cell Physiology 48: 866-874. (#These authors contributed equally)
Hua Li, Ming Yuan, Tonglin Mao* (2007) AtMAP65-1 Binds to Tubulin Dimers to Promote Tubulin Assembly.Journal of Biochemistry and Molecular Biology 40 : 218-225.
Tonglin Mao, Lifeng Jin, Hua Li, Bo Liu, and Ming Yuan (2005) Two Microtubule-Associated Proteins of the Arabidopsis MAP65 Family Function Differently on Microtubules.Plant Physiology 138: 654–662.