课题组长

English
傅缨
职称:教授
联系电话:86-10-62734395 (O);86-10-62731323 (L)
E-mail:yingfu@cau.edu.cn
研究方向:细胞骨架与植物细胞生长调控
傅缨,博士,教授,博士生导师
    1993年毕业于华中师范大学生物学系,获理学学士;1999年获武汉大学植物学专业理学博士学位。1999年-2004年在美国加州大学河滨分校植物科学系从事博士后研究,2004-2007年在该校任职Assistant Project Scientist。2007年被聘为中国农业大学生物学院教授。
主要研究方向
细胞骨架与植物细胞生长调控

 高等植物的个体由众多形态各异的不同类型细胞所组成,植物细胞生长过程对于细胞乃至植物整体的生长发育和形态建成(morphogenesis)至关重要,我们实验室主要研究细胞骨架响应信号分子调控植物细胞生长和形态建成的分子机理。

 1、细胞骨架响应植物体内生长发育信号调控细胞极性生长。植物细胞的生长控制涉及分子和细胞水平诸多方面的调控。其中,细胞骨架已经被充分证明在植物细胞的生长以及形态建成方面有重要的功能。我们重点研究介导植物激素(如生长素)调控细胞生长的信号转导途径,包括植物中重要的信号分子ROP GTPase如何通过调控细胞骨架决定植物细胞极性生长和形态发生的分子调控机制,以及作用于细胞骨架的不同信号转导途径间的交互作用。同时也探讨ROPs-细胞骨架途径调控生长素极性运输的分子机制。不同信号途径对细胞骨架组织与动态的调控往往通过细胞骨架结合蛋白来完成,我们也致力发现新的细胞骨架结合蛋白或已知结合蛋白的新功能。


被生长素激活的ROP6-RIC1信号转导途径调控微管剪切蛋白KTN1的活性促进微管排列成平行有序的列阵。(Current Biology. 2013, 23: 290-297)

 2、细胞骨架响应环境信号调控细胞生长和气孔运动。环境中的信号(如光、非生物逆境胁迫信号等)对植物生长起重要调控作用。已有研究表明这些环境信号往往可以通过调节细胞骨架的组织、排列来调控植物细胞的生长,我们研究在这一过程中发挥功能的细胞骨架结合蛋白,以及传递信号的信号转导机制。此外,气孔运动的调控对于植物响应非生物逆境信号具有重要意义,而气孔运动依赖于细胞骨架。我们亦关注对细胞骨架调控气孔开放、闭合分子机制的深入解析。
发表论文/论著    (*通讯作者)

  *Correspondence author; #Co-first author

Li C#, Shi L#, Wang Y, Li W, Chen B, Zhu L, Fu Y*. 2020. Arabidopsis ECAP is a new adaptor protein that connects JAZ repressors with TPR2 co-repressor to suppress Jasmonate-responsive anthocyanin accumulation. Molecular Plant. 13:246-265

Li W, Ge F, Qiang Z, Zhu L, Zhang S, Chen L, Wang X*, Li J*, Fu Y*. 2020. Maize ZmRPH1 encodes a microtubule-associated protein that controls plant and ear height. Plant Biotechnology Journal. 18:1345-1347

Tian L, Zhang Y, Kang E, Ma H, Zhao H, Yuan M, Zhu L*, Fu Y. 2019. Basic-leucine zipper17 and Hmg-CoA reductase degradation 3A are involved in salt acclimation memory in Arabidopsis. Journal of Integrative Plant Biology. 61:1062-1084

He M, Lan M, Zhang B, Zhou Y, Wang Y, Zhu L, Yuan M, Fu Y*. 2018. Rab-H1b is essential for trafficking of cellulose synthase and for hypocotyl growth in Arabidopsis thaliana. Journal of Integrative Plant Biology. 60:1051-1069

Lan Y, Liu X, Fu Y*, Huang S*. 2018. Arabidopsis class I formins control membrane-originated actin polymerization at pollen tube tips. PLoS Genetics. 14:e1007789. doi: 10.1371/journal.pgen.1007789

Li C#, Lu H#, Li W, Yuan M, Fu Y*. 2017. A ROP2-RIC1 pathway fine-tunes microtubule reorganization for salt tolerance in Arabidopsis. Plant, Cell and Environment. 40:1127-1142

Kang E, Zheng M, Zhang Y, Yuan M, Yalovsky S, Zhu L*, Fu Y. 2017. MAP18 regulates the activity of ROP2 GTPase during root hair growth in Arabidopsis thaliana. Plant Physiology. 174:202-222

Fu Y*. 2015. The cytoskeleton in the pollen tube. Current Opinion in Plant Biology. 28:111-119

Zhou Z#, Shi H#, Chen B#, Zhang R, Huang S, Fu Y*. 2015. Arabidopsis RIC1 severs actin filaments at the apex to regulate pollen tube growth. The Plant Cell. 27: 1140-1161

Zhang Y, Kang E, Yuan M, Fu Y, Zhu L*. 2015. PCaP2 regulates nuclear positioning in growing Arabidopsis thaliana root hairs by modulating filamentous actin organization. Plant Cell Report. 34:1317-1330

Zhu L, Zhang Y, Kang E, Xu Q, Wang M, Rui Y, Liu, B, Yuan M, Fu Y*. 2013. Map18 regulates the direction of pollen tube growth in Arabidopsis by modulating F-actin. The Plant Cell. 25: 851-867

Lin D#, Cao L#, Zhou Z, Zhu L, Ehrhardt D, Yang Z, Fu Y*. 2013. Rho GTPase signaling activates microtubule severing to promote microtubules ordering in Arabidopsis. Current Biology. 23: 290-297

Zhu L, Fu Y*. 2012. Analysis of in vivo ROP GTPase activity at the subcellular level by fluorescence resonance energy transfer microscopy. Plant Signalling Networks, Methods and Protocols. Edited by Wang ZY. and Yang Z. Humana Press. pp 145-152

Fu Y, Yang Z. 2011. Signaling to the cytoskeleton in diffuse cell growth. The Plant Cytoseleton. Edited by Liu B. Springer Science+Business Media, LLC. Vol 2, pp 229-243

Fu Y*. 2010. ROP GTPases and the Cytoskeleton. Integrated G Proteins Signaling in Plants. Edited by Yalovsky S. et al. Springer-Verlag Berlin Heidelberg. pp 91-104

Fu Y*. 2010. The actin cytoskeleton and signaling network during pollen tube tip growth. Journal of Integrative Plant Biology. 52: 131-137

Fu Y*, Xu T, Zhu L, Wen M, Yang Z*. 2009. A ROP GTPase signaling pathway controls cortical microtubule ordering and cell expansion in Arabidopsis. Current Biology.19: 1827-1832

Zhou L, Fu Y* and Yang, Z*. 2009. A genome-wide functional characterization of Arabidopsis regulatory calcium sensors in pollen tubes. Journal of Integrative Plant Biology. 51: 751-61

Fu Y, Yang Z, Kawasaki T, Shimamoto K. 2008. ROP/Rac GTPases. Chapter 3 in Intracellular Signalling in Plants. Edited by Yang Z. Blackwell Publishing, Oxford, UK. pp 64-99

Yang Z*, Fu Y. 2007. ROP/RAC GTPase signaling. Current Opinion in Plant Biology. 10:490-494

Fu Y#, Gu Y#, Zheng Z, Wasteneys G, and Yang Z. 2005. Arabidopsis Interdigitating Cell growth requires two antagonistic pathways with opposing action on cell morphogenesis. Cell. 120: 687-700

Fu Y, Li H, Yang Z. 2002.  The Rop2 GTPase controls the formation of cortical fine F-actin and the early phase of directional cell expansion during Arabidopsis organogenesis. The Plant Cell. 14: 777-794

Fu Y, Wu G., Yang Z. 2001.  Rop GTPase-Dependent dynamics of tip-localized F-actin controls tip growth in pollen tubes. Journal of Cell Biology. 152: 1019-1032

Fu, Y. and Yang Z.  2001.  The Rop GTPase: A master switch of cell polarity development in plants.  Trends in Plant Science 6: 545-547

Yuan M#, Fu Y#, Wang F, Huang B-Q, Zee, S-Y.  and Hepler PK. 2002. Fertilization in Torenia fournieri: actin organization and nuclear behavior in the central cell and primary endosperm. Science in China. 45: 211-224

Fu Y, Yuan M, Huang B-Q, Yang H-Y, Zee S-Y, and O’Brien TP. 2000. Changes in actin organization in the living egg apparatus of Torenia fournieri during fertilization. Sexual Plant Reproduction. 12: 315-322