傅缨
职称：教授
联系电话：86-10-62734395 (O)；86-10-62731323 (L)
E-mail：yingfu@cau.edu.cn
研究方向：细胞骨架与植物细胞生长调控 | | 傅缨，博士，教授，博士生导师
1993年毕业于华中师范大学生物学系，获理学学士；1999年获武汉大学植物学专业理学博士学位。1999年－2004年在美国加州大学河滨分校植物科学系从事博士后研究，2004－2007年在该校任职Assistant Project Scientist。2007年被聘为中国农业大学生物学院教授。2008年获得教育部“新世纪优秀人才支持计划”资助。 主持或参与多项国家自然科学基金项目，国家重点基础研究项目(973项目)等。 |
| | 主要研究方向 | 细胞骨架与植物细胞生长调控
高等植物的个体由众多形态各异的不同类型细胞所组成，植物细胞生长过程对于细胞乃至植物整体的生长发育和形态建成(morphogenesis)至关重要，我们实验室主要研究细胞骨架响应信号分子调控植物细胞生长和形态建成的分子机理。
1、细胞骨架响应植物体内生长发育信号调控细胞极性生长。植物细胞的生长控制涉及分子和细胞水平诸多方面的调控。其中，细胞骨架已经被充分证明在植物细胞的生长以及形态建成方面有重要的功能。我们重点研究介导植物激素(如生长素)调控细胞生长的信号转导途径，包括植物中重要的信号分子ROP GTPase如何通过调控细胞骨架决定植物细胞极性生长和形态发生的分子调控机制，以及作用于细胞骨架的不同信号转导途径间的交互作用。同时也探讨ROPs-细胞骨架途径调控生长素极性运输的分子机制。不同信号途径对细胞骨架组织与动态的调控往往通过细胞骨架结合蛋白来完成，我们也致力发现新的细胞骨架结合蛋白或已知结合蛋白的新功能。
被生长素激活的ROP6-RIC1信号转导途径调控微管剪切蛋白KTN1的活性促进微管排列成平行有序的列阵。(Current Biology. 2013, 23: 290-297)
2、细胞骨架响应环境信号调控细胞生长和气孔运动。环境中的信号(如光、非生物逆境胁迫信号等)对植物生长起重要调控作用。已有研究表明这些环境信号往往可以通过调节细胞骨架的组织、排列来调控植物细胞的生长，我们研究在这一过程中发挥功能的细胞骨架结合蛋白，以及传递信号的信号转导机制。此外，气孔运动的调控对于植物响应非生物逆境信号具有重要意义，而气孔运动依赖于细胞骨架。我们亦关注对细胞骨架调控气孔开放、闭合分子机制的深入解析。
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| | 发表论文/论著 （*通讯作者） | Zhu L, Zhang Y, Kang E, Xu Q, Wang M, Rui Y, Liu, B, Yuan M, Fu Y*. 2013. Map18 regulates the direction of pollen tube growth in Arabidopsis by modulating F-actin. The Plant Cell. (online)
Lin D, Cao L, Zhou Z, Zhu L, Ehrhardt D, Yang Z, Fu Y*. 2013. Rho GTPase signaling activates microtubule severing to promote microtubules ordering in Arabidopsis. Current Biology. 23: 290-297
Zhu L, Fu Y*. 2012. Analysis of in vivo ROP GTPase activity at the subcellular level by fluorescence resonance energy transfer microscopy. Plant Signalling Networks, Methods and Protocols. Edited by Wang ZY. and Yang Z. Humana Press. pp 145-152
Lin D, Nagawa S, Chen J, Cao L, Chen X, Li H, Dhonukshe P, Yamamuro C, Friml J, Scheres B, Fu Y, Yang Z. 2012. A ROP GTPase-dependent auxin signaling pathway regulates the subcellular distribution of PIN2 in Arabidopsis roots. Current Biology. 22: 1319-1325
Nagawa S, Xu T, Lin D, Dhonukshe P, Zhang X, Friml J, Scheres B, Fu Y, Yang Z. 2012. ROP GTPase-dependent actin microfilaments promote PIN1 polarization by localized inhibition of clathrin-dependent endocytosis. PLoS Biology. 10(4): e1001299. doi:10.1371/journal.pbio.1001299
Fu Y, Yang Z. 2011. Signaling to the cytoskeleton in diffuse cell growth. The Plant Cytoseleton. Edited by Liu B. Springer Science+Business Media, LLC. Vol 2, pp 229-243
Xu T, Wen M, Nagawa S, Fu Y, Chen JG, Wu MJ, Perrot-Rechenmann C, Friml J, Jones AM, Yang Z. 2010. Cell surface- and Rho GTPase-based auxin signaling controls cellular interdigitation in Arabidopsis. Cell. 143: 99-110
Fu Y*. 2010. ROP GTPases and the Cytoskeleton. Integrated G Proteins Signaling in Plants. Edited by Yalovsky S. et al. Springer-Verlag Berlin Heidelberg. pp 91-104
Fu Y*. 2010. The actin cytoskeleton and signaling network during pollen tube tip growth. Journal of Integrative Plant Biology. 52: 131-137
Fu Y*, Xu T, Zhu L, Wen M, Yang Z*. 2009. A ROP GTPase signaling pathway controls cortical microtubule ordering and cell expansion in Arabidopsis. Current Biology.19: 1827-1832
Zhou L, Fu Y* and Yang, Z*. 2009. A genome-wide functional characterization of Arabidopsis regulatory calcium sensors in pollen tubes. Journal of Integrative Plant Biology. 51: 751-61
Jeon BW, Hwang JU, Hwang Y, Song WY, Fu Y, Gu Y, Bao F, Cho D, Kwak JM, Yang Z, Lee Y. 2008. The Arabidopsis small G protein ROP2 is activated by light in guard cells and inhibits light-induced stomatal opening. Plant Cell. 20: 75-87
Fu Y, Yang Z, Kawasaki T, Shimamoto K. 2008. ROP/Rac GTPases. Chapter 3 in Intracellular Signalling in Plants. Edited by Yang Z. Blackwell Publishing, Oxford, UK. pp 64-99
Yang Z, Fu Y. 2007. ROP/RAC GTPase signaling. Current Opinion in Plant Biology. 10: 490-494
Fu Y, Gu Y, Zheng Z, Wasteneys G, and Yang Z. 2005. Arabidopsis Interdigitating Cell growth requires two antagonistic pathways with opposing action on cell morphogenesis. Cell. 120: 687-700
Gu Y, Fu Y, Dowd P, Li S , Vernoud V, Gilroy S, and Yang Z. 2005. A Rho family GTPase controls actin dynamics and tip growth via two counteracting downstream pathways in pollen tubes. Journal of Cell Biology. 169: 127-138
Fu Y, Li H, Yang Z. 2002. The Rop2 GTPase controls the formation of cortical fine F-actin and the early phase of directional cell expansion during Arabidopsis organogenesis. The Plant Cell. 14: 777-794
Fu Y, Wu G., Yang Z. 2001. Rop GTPase-Dependent dynamics of tip-localized F-actin controls tip growth in pollen tubes. Journal of Cell Biology. 152: 1019-1032
Fu, Y. and Yang Z. 2001. The Rop GTPase: A master switch of cell polarity development in plants. Trends in Plant Science 6: 545-547
Gu Y, Vernoud V, Fu Y, and Yang Z. 2003. ROP GTPase regulation of pollen tube growth through the dynamics of tip-localized F-actin. Journal of Experimental Botany. 54: 93-101
Jones MA, Shen J, Li H, Fu Y, Yang Z , Grierson CS. 2002. The Arabidopsis Rop2 GTPase is a Positive Regulator of both Root Hair Initiation and Tip Growth. The Plant Cell. 14: 763-776.
Yuan M1, Fu Y,1 Wang F, Huang B-Q, Zee, S-Y. and Hepler PK. 2002. Fertilization in Torenia fournieri: actin organization and nuclear behavior in the central cell and primary endosperm. Science in China. 45: 211-224 1Co-first authors
Fu Y, Yuan M, Huang B-Q, Yang H-Y, Zee S-Y, and O’Brien TP. 2000. Changes in actin organization in the living egg apparatus of Torenia fournieri during fertilization. Sexual Plant Reproduction. 12: 315-322
Huang B-Q, Fu Y, Zee S-Y and Hepler P. 1999. Three-dimensionalorganization and dynamic changes of the actin cytoskeleton in embryo sacs of Zea mays and Torenia fournieri. Protoplasma. 209: 105-119
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