课题组长

English

巩志忠,教授,博士研究生导师,长江学者特聘教授,中国农业大学生物学院院长,中国农业大学生物学院学术委员会主任。Plant  Physiology(2006-)、Plant Cell and Physiology (2013-),Physiologia  Plantarum(2006-)、《植物学报》编委、《科学通报》特邀编辑。1998年获得日本千叶大学博士学位,1999-2000年在美国普渡大学(Purdue  University)植物环境生理中心Mike  Hasegawa及Ray  Bressan教授研究室从事植物抗逆的分子生物学研究。2000-2002年在美国亚利桑那大学(The  University  of  Arizona)植物系朱健康教授(Jian-Kang  Zhu)研究室继续从事植物抗逆的分子生物学及基因沉默的研究。2002年被聘为中国农业大学教授,同年获“国家杰出青年基金”资助  (2003-2006);2003年被科技部聘为国家重点基础研究项目(973项目)“作物高效抗旱的分子生物学和遗传学基础”首席科学家,2004年入选新世纪百千万人才工程国家级人选,2005年获教育部长江学者特聘教授。2006年获中国青年科技奖。 

1983年9月-1987年6月,山东师范大学生物系,学士;    
1987年9月-1990年5月,中国科学院植物研究所,硕士;    
1995年3月-1998年2月,日本千叶大学药学系,博士。    
1990年6月-1993年9月,中国科学院植物研究所,助理研究员;    
1994年10月-1995年2月,日本千叶大学药学系,访问学者;    
1998年3月-1999年2月,日本千叶大学药学系,博士后;    
1999年3月-2000年7月,美国普渡大学农学院园艺学系,博士后;    
2000年8月-2002年7月,美国亚利桑那大学农学院植物系,博士后;    
2002年7月-今,中国农业大学生物学院,教授;
主要研究方向
  主要研究方向:主要从事植物抗旱的分子机理以及不依赖于RdDM途径的转录基因沉默分子机理研究
发表论文/论著    (*通讯作者)

 

2017

Liu Z, Jia Y, Ding Y, Shi Y, Zhang X, Li Z, Guo Y, Gong Z, Yang S*. Plasma membrane CRPK1-mediated phosphorylation of 14-3-3 proteins induces their nuclear translocation to fine-tune CBF signaling during cold response. Mol Cell, 2017  66: 117-128..

Promchuea S, Zhu Y, Chen Z, Zhang J, Gong Z*. ARF2 coordinates with PLETHORAs and PINs to orchestrate ABA-mediated root meristem activity in Arabidopsis . Integr Plant Biol. 2017, 59:30-43.

Liu L, Yan X, Kong X, Zhao Y, Gong Z, Jin JB, Guo Y. Transcriptional Gene Silencing Maintained by OTS1 SUMO Protease Requires a DNA-Dependent Polymerase V-Dependent Pathway. Plant Physiol. 2017;173: 655-667.

Meng Z, Ruberti C, Gong Z, Brandizzi F. CPR5 modulates salicylic acid and the unfolded protein response to manage tradeoffs between plant growth and stress responses. Plant J. 2017; 89: 486-501.

Huang X, Zhang X, Gong Z, Yang S, Shi Y. ABI4 represses the expression of type-A ARRs to inhibit seed germination in Arabidopsis. Plant J. 2017;89: 354-365.

2016

Zhang Q, Li Y, Xu T, Srivastava AK, Wang D, Zeng L, Yang L, He L, Zhang H, Zheng Z, Yang DL, Zhao C, Dong J, Gong Z, Liu R, Zhu JK. The chromatin remodeler DDM1 promotes hybrid vigor by regulating salicylic acid metabolism. Cell Discov. 2016; 2: 16027.

Jia Y, Ding Y, Shi Y, Zhang X, Gong Z, Yang S*. The cbfs triple mutants reveal the essential functions of CBFs in cold acclimation and allow the definition of CBF regulons in Arabidopsis. New Phytol. 2016; 212: 345-53.

Lang Z*, Gong Z*. Small RNA biogenesis: Novel roles of an RNase III enzyme. Nat Plants. 2016; 2:16021.

Zhang J, Xie S, Zhu JK, Gong Z*. Requirement for flap endonuclease 1 (FEN1) to maintain genomic stability and transcriptional gene silencing in Arabidopsis. Plant J. Plant J. 2016; 87: 629-40

Zhang J, Xie S, Cheng J, Lai J, Zhu JK, Gong Z*. The Second Subunit of DNA Polymerase Delta Is Required for Genomic Stability and Epigenetic Regulation. Plant Physiol. 2016, 171:1192-208.

2015

Kong L, Cheng J, Zhu Y, Ding Y, Meng J, Chen Z, Xie Q, Guo Y, Li J, Yang S, Gong Z*. Degradation of the ABA co-receptor ABI1 by PUB12/13 U-box E3 ligases. Nat Commun. 2015, 6:8630.

Zheng Z, Yu H, Miki D, Jin D, Zhang Q, Ren Z, Gong Z, Zhang H, Zhu JK*. Involvement of Multiple Gene-Silencing Pathways in a Paramutation-like Phenomenon in Arabidopsis. Cell Rep. 2015, 11:1160-7.

Ding Y, Li H, Zhang X, Xie Q, Gong Z, Yang S*. OST1 kinase modulates freezing tolerance by enhancing ICE1 stability in Arabidopsis. Dev Cell. 2015, 32:278-89.

Zheng Z, Yu H, Miki D, Jin D, Zhang Q, Ren Z, Gong Z, Zhang H, Zhu JK*. Involvement of Multiple Gene-Silencing Pathways in a Paramutation-like Phenomenon in Arabidopsis. Cell Rep. 2015,11:1160-7.

Shi Y, Gong Z. One SNP in COLD1 Determines Cold Tolerance during Rice Domestication. J Genet Genomics. 2015, 42:133-4.

Lang Z, Lei M, Wang X, Tang K, Miki D, Zhang H, Mangrauthia SK, Liu W, Nie W, Ma G, Yan J, Duan CG, Hsu CC, Wang C, Tao WA, Gong Z, Zhu JK*. The methyl-CpG-binding protein MBD7 facilitates active DNA demethylation to limit DNA hyper-methylation and transcriptional gene silencing. Mol Cell. 2015, 57:971-83.

Wang C, Dong X, Jin D, Zhao Y, Xie S, Li X, He X, Lang Z, Lai J, Zhu JK, Gong Z*. Methyl-CpG-binding domain protein MBD7 is required for active DNA demethylation in Arabidopsis. Plant Physiol. 2015, 167:905-14.

2014

Yang L, Zhang J, He J, Qin Y, Hua D, Duan Y, Chen Z, Gong Z*. ABA-Mediated ROS in Mitochondria Regulate Root Meristem Activity by Controlling PLETHORA Expression in Arabidopsis. PLoS Genet. 2014, 10(12): e1004791.

Zhao Y, Xie S, Li X, Wang C, Chen Z, Lai J, Gong Z*. REPRESSOR OF SILENCING5 Encodes a Member of the Small Heat Shock Protein Family and Is Required for DNA Demethylation in Arabidopsis. Plant Cell. 2014, 26:2660-2675.

Luo X, Chen Z, Gao J, Gong Z*. Abscisic acid inhibits root growth in Arabidopsis through ethylene biosynthesis. Plant J. 2014, 79:44-55.

2013

Yao T, Jin D, Liu Q, Gong Z*. Abscisic acid suppresses the highly occurred somatic homologous recombination in Arabidopsis rfc1 mutant. J Genet Genomics. 2013, 40:465-71.

Zhang X, Jiang L, Wang G, Yu L, Zhang Q, Xin Q, Wu W, Gong Z, Chen Z*. Structural insights into the abscisic acid stereospecificity by the ABA receptors PYR/PYL/RCAR. PLoS One. 2013; 8(7):e67477.


2012

Wang Y, Cheng Z, Huang J, Shi Q, Hong Y, Copenhaver GP, Gong Z, Ma H*. The DNA replication factor RFC1 is required for interference-sensitive meiotic crossovers in Arabidopsis thaliana. PLoS Genet. 2012 8: e1003039.

Li X, Qian W, Zhao Y, Wang C, Shen J, Zhu J-K*, and Gong Z*. Antisilencing role of the RNA-directed DNA methylation pathway and a histone acetyltransferase in Arabidopsis. Proc. Natl. Acad. Sci., 2012, 109,11425-11430.


Qian W, Miki D, Zhang H, Liu Y, Zhang X, Tang K, Kan Y, La H, Li X, Li S, Zhu X, Shi X, Zhang K, Pontes O, Chen X, Liu R, Gong Z, Zhu JK*.A histone acetyltransferase regulates active DNA demethylation in Arabidopsis. Science, 2012, 336:1445-8.


Hua D#, Wang C#, He J, Liao H, Duan Y,Zhu Z, Guo Y, Gong Z*. A Plasma Membrane Receptor Kinase, GHR1, Mediates ABA- and H2O2-regulated Stomatal Movement in Arabidopsis. Plant Cell, 2012, 24: 2546-2561(#: equal contribution).

He J,Duan Y, Hua D, Fan G, Wang L, Liu Y, Chen Z, Qu L-J, Gong Z*. DEXH-box RNA helicase-mediated mitochondrial ROS production in Arabidopsis mediates cross-talk between Abscisic acid and auxin signalling. Plant Cell, 2012, 24:1815-1833.


Zhang X, Zhang Q, Xin Q, Yu L, Wang Z, Wu W, Jiang L, Wang G, Tian W, Deng Z, Wang Y, Liu Z, Long J, Gong Z, Chen Z*. Complex structures of the abscisic acid receptor PYL3/RCAR13 reveal a unique regulatory mechanism. Structure. 2012, 20:780-90.

2011

Gong Z*, Zhu J-K. Active DNA demethylation by oxidation and repair. Cell Research, 2011, 21:1649-1651.

Wang L, Hua D, He J, Duan Y, Chen Z, Hong X, Gong Z*. Auxin Response Factor2 (ARF2) and its regulated homeodomain gene HB33 mediate abscisic acid response in Arabidopsis. PLOS Genetics, 2011 7:e1002172.

Liu Q, Gong Z*.  The coupling of epigenome replication with DNA replication. Current Opinion in Plant Biology. 2011, 14: 187-194

2010

Liu Q, Wang J, Miki D, Xia R, Yu W, He J, Zheng Z, Zhu J-K, Gong Z*. DNA replication factor C1 mediates genomic stability and transcriptional gene silencing in Arabidopsis. Plant Cell, 2010, 22:2336-2352.


Liu Y, He, J, Chen Z, Ren X, Hong X, Gong, Z*. ABA Overly-Sensitive5 (ABO5), encoding a pentatricopeptide repeat protein required for cis-splicing of mitochondrial nad2 intron 3, is involved in abscisic acid response in Arabidopsis. Plant J 2010, 63, 749-765.


Ren X, Chen Z, Liu Y, Zhang H, Zhang M, Liu Q, Hong X, Zhu J-K, Gong Z*. ABO3, a WRKY transcription factor, mediates plant responses to abscisic acid and drought tolerance in Arabidopsis. Plant J 2010, 63, 417-429.

Liu J, Ren X, Yin H, Wang Y, Xia R, Wang Y, Gong Z*. Mutation in the catalytic subunit of DNA polymerase alpha influences transcriptional gene silencing and homologous recombination in Arabidopsis. Plant J 2010, 61, 36-45.


2009

Zhang M, Henquet M , Chen Z, Zhang H, Zhang Y, Ren X, van der Krol S, Gonneau M, Bosch D and Gong Z* . LEW3 encoding a putative alpha-1, 2-mannosyltransferase (ALG11) in N-linked glycoprotein plays vital roles in cell wall biosynthesis and abiotic stress response in Arabidopsis. Plant J 2009 60, 983-999.


Shen J, Ren X, Cao R, Liu J, Gong, Z*. Transcriptional gene silencing mediated by a plastid inner envelope phosphoenolpyruvate/phosphate translocator CUE1 in Arabidopsis. Plant Physiol. 2009 150: 1990-1996.


Zhou X, Hua D, Chen Z, Zhou Z, Gong, Z*.  Elongator mediates ABA responses, oxidative stress resistance, and anthocyanin biosynthesis in Arabidopsis. Plant J 2009 60:79-90.


Yin H, Zhang X, Liu J, Wang Y, He J, Yang T, Hong X, Yang Q, Gong Z*. Epigenetic regulation, somatic homologous recombination and abscisic acid signaling are influenced by DNA polymerase ε mutation in Arabidopsis. Plant Cell, 2009 21:386-402.


Yang Q,  Chen Z,  Zhou X,  Yin H,  Li X,  Xin X, Hong X, Zhu J-K, Gong Z*. Overexpression of SOS (Salt Overly Sensitive) genes increases the salt tolerance in transgenic Arabidopsis. Mol Plant, 2009; 2: 22 – 31

2008

Chinnusamy V, Gong Z, Zhu JK. 2008. Nuclear RNA export and its importance in abiotic stress responses of plants. Curr. Top. Microbiol. Immunol. 326:235-255.


Chinnusamy V, Gong Z*, Zhu JK. 2008. Abscisic Acid-mediated Epigenetic Processes in Plant Development and Stress Responses. JIPB. 50, 1187–1195.


Zhang H, Ohyama K,  Boudet J, Chen Z, Yang J, Zhang M,Muranaka T, Maurel C, Zhu J-K, and  Gong Z*. Dolichol Biosynthesis and Its Effects on the Unfolded Protein Response and Abiotic Stress Resistance in Arabidopsis. Plant Cell. 2008  20: 1879-1898.

2007

Zhao J, Zhang W, Zhao Y, Gong X, Guo L, Zhu G, Wang X, Gong Z, Schumaker KS, Guo Y. SAD2, an importin -like protein, is required for UV-B response in Arabidopsis by mediating MYB4 nuclear trafficking. Plant Cell. 2007 19: 3805-18.


Wang Y, Liu J, Xia R, Wang J, Shen J, Cao R, Hong X, Zhu J-K, Gong Z*. The protein kinase TOUSLED is required for maintenance of transcriptional gene silencing in Arabidopsis. EMBO R. 8, 1, 77–83 (2007).


2006

Chen Z, Zhang H, Jablonowski D, Zhou X, Ren X, Hong X, Schaffrath R, Zhu J-K, Gong Z*. Mutations in ABO1/ELO2, a subunit of holo-elongator, increase ABA sensitivity and drought tolerance in Arabidopsis. Mol. Cell. Biol. 2006, 26: 6902–6912.


Xia R, Wang J, Liu C, Wang Y, Wang Y, Zhai J, Liu J, Hong X, Cao X, Zhu JK, Gong Z*. ROR1/RPA2A, a putative replication protein A2, functions in epigenetic gene silencing and in regulation of meristem development in Arabidopsis. Plant Cell. 2006 18:85-103.

2005

Kapoor A, Agarwal M, Andreucci A, Zheng X, Gong Z, Hasegawa PM, Bressan RA, Zhu JK. Mutations in a conserved replication protein suppress transcriptional gene silencing in a DNA-methylation-independent manner in Arabidopsis. Curr Biol. 2005 15:1912-8.


Chen Z, Hong X, Zhang H, Wang Y, Li X, Zhu JK, Gong Z*. Disruption of the cellulose synthase gene, AtCesA8/IRX1, enhances drought and osmotic stress tolerance in Arabidopsis. Plant J. 2005 43:273-83.


Gong Z
, Dong CH, Lee H, Zhu J, Xiong L, Gong D, Stevenson B, Zhu JK. A DEAD box RNA helicase is essential for mRNA export and important for development and stress responses in Arabidopsis. Plant Cell. 2005 17:256-67.

2004

Wang, Z-L, Li, P-H, Fredricksen, M, Gong Z, Kim, CS, Zhang, C, Bohnert, HJ, Zhu, J-K, Bressan, RA, Hasegawa, PM, Zhao, Y-X, Zhang, H 2004.  Expressed seqeunce tags from Thellungiella halophila, a new model to study plant salt-tolerance. Plant Sci. 166:609-616.

2002

Gong Z, Morales-Ruiz T, Ariza R. R. , Roldán-Arjona T, David L, Zhu JK. ROS1, a repressor of transcriptional gene silencing in Arabidopsis, encodes a DNA glycosylase/lyase. Cell 2002 111:803-14.


Zhu J, Gong Z, Zhang C, Song CP, Damsz B, Inan G, Koiwa H, Zhu JK, Hasegawa PM, Bressan RA. OSM1/SYP61: a syntaxin protein in Arabidopsis controls abscisic acid-mediated and non-abscisic acid-mediated responses to abiotic stress. Plant Cell. 2002 14:3009-28.


Gong, D., Zhang, C., Chen, X., Gong, Z., and Zhu, J.-K. 2002. Constitutive activation and transgenic evaluation of the function of an Arabidopsis PKS protein kinase. J. Biol. Chem. 2002 277:42088-96.

Gong, Z., Lee, H., Xiong, L., Jagendorf, A., Stevenson, B., and Zhu, J.-K. 2002. RNA helicase-like protein as an early regulator of transcription factors for plant chilling and freezing tolerance. Proc. Natl. Acad. Sci. 99:11507-11512.

Koiwa, H., Barb, A.W., Xiong, L., Li, F., McCully, M.G., Lee, B.-H., Sokolchik, I., Zhu, J., Gong, Z., Reddy, M., Sharkhuu, A., Manabe, Y., Yokoi, S., Zhu, J.-K., Bressan, R.A., and Hasegawa, P.M. 2002. C-terminal domain phosphatase-like family members (AtCPLs) differentially regulate Arabidopsis thaliana abiotic stress signaling, growth, and development. Proc. Natl. Acad. Sci. USA. 99:10893-10898.


Yamazaki M, Yamagishi E, Gong Z, Fukuchi-Mizutani M, Fukui Y, Tanaka Y, Kusumi T, Yamaguchi M, Saito K. Two flavonoid glucosyltransferases from Petunia hybrida: molecular cloning, biochemical properties and developmentally regulated expression. Plant Mol Biol. 2002, 48:401-11.


Gong, D., Gong, Z., Guo, Y., Chen, X., Zhu, J.-K. 2002. Biochemical and functional characterization of PKS11, a novel Arabidopsis protein kinase. J. Biol. Chem. 277:28340-28350.


Gong, D., Gong, Z. and Zhu, J.-K. 2002. Expression, activation and biochemical properties of a novel Arabidopsis protein kinase.  Plant Physiol. 129:225-234.

2001

Li X, Gong Z, Koiwa H, Niu X, Espartero J, Zhu X, Veronese P, Ruggiero B, Bressan R,. Weller SC,.Hasegawa PM. Bar Expressing Peppermint (Mentha X Piperita L. var. Black Mitcham) Plants Are Highly Resistant to the Glufosinate Herbicide Liberty. Molecular Breeding. 2001, 8: 109-118.

Xiong L, Gong Z, Rock CD, Subramanian S, Guo Y, Xu W, Galbraith D, Zhu JK. Modulation of abscisic acid signal transduction and biosynthesis by an Sm-like protein in Arabidopsis.
Dev Cell. 2001 (6):771-81.


Gong Z
, Koiwa H, Cushman MA, Ray A,Bufford D, Kore-eda S, Matsumoto T, Zhu J, Cushman J, Bressan R, Hasegawa M Genes that are uniquely stress-regulated in salt overly sensitive(sos) mutants. Plant Physiol. 2001, 126: 363-375.

Kitada C, Gong Z, Tanaka Y, Yamazaki M, Saito K.Differential expression of two cytochrome P450s involved in the biosynthesis of flavones and anthocyanins in chemo-varietal forms of Perilla frutescens. Plant Cell Physiol. 2001 42:1338-44.


Lee H, Xiong L, Gong Z, Ishitani M, Stevenson B, Zhu JK. The Arabidopsis HOS1 gene negatively regulates cold signal transduction and encodes a RING finger protein that displays cold-regulated nucleo-cytoplasmic partitioning . Genes & Deve  15 : 912-924(2001).

2000

Gong Z, Yamazaki M, Saito K(2000) Critical role of alanine-161 in Delila protein involved in regulation of anthocyanin pigmentation for transcriptional activation in yeast. Plant Biotech, 17, 309-314.


1999

Yamazaki M1, Gong Z1, Fukuchi-Mizutani M, Fukui Y, Tanaka Y, Kusumi T, Saito K. Molecular cloning and biochemical characterization of a novel anthocyanin 5-O-glucosyltransferase by mRNA differential display for plant forms regarding anthocyanin. J Biol Chem 1999, 274:7405-11. (1: Equal contribution)


Gong Z
, Yamagishi E, Yamazaki M, Saito K A constitutively expressed Myc-like gene involved in anthocyanin biosynthesis from Perilla frutescens: molecular characterization, heterologous expression in transgenic plants and transactivation in yeast cells. Plant Mol Biol 1999, 41:33-44.


Gong Z
, Yamazaki M, Saito K. A light-inducible Myb-like gene that is specifically expressed in red Perilla frutescens and presumably acts as a determining factor of the anthocyanin forma. Mol Gen Genet 1999, 262: 65-72.


Saito K, Kobayashi M, Gong Z, Tanaka Y, Yamazaki M Direct evidence for anthocyanidin synthase as a 2-oxoglutarate-dependent oxygenase: molecular cloning and functional expression of cDNA from a red forma of Perilla frutescens. Plant J 1999, 17:181-9.

1998

Yamagishi E, Gong Z, Yamazaki M,  Saito K. Molecular cloning of a cDNA encoding a novel UDP-glucose glucosyltransferase homologue from Arabidopsis thaliana (Accession No. AB016819). Plant Physiol., 1998, 118, 1102.

1997

Gong Z, Yamazaki M, Sugiyama M, Tanaka Y, Saito K. Cloning and molecular analysis of structural genes involved in anthocyanin biosynthesis and expressed in a forma-specific manner in Perilla frutescens. Plant Mol Biol 1997, 35: 915-27